The Minister for Enterprise, Trade & Employment is the person who is reponsible for the implementation of Government policy under five key areas in the Department of Enterprise, Trade & Employment- Enterprise, Innovation, Growth; Quality Work and Learning; Making Markets and Regulation work better; Quality, Value and Continuous Improvement; and the European Union. A large element of the work of the Department arises from Ireland's membership of a number of international organisations, in particular the European Union and the World Trade Organisation. The Department plays an active role in the development of EU and WTO policies, particularly to ensure that Ireland's interests are protected.
The Department of Enterprise, Trade and Employment is organised into seven divisions. They are:
This portfolio has changed names a number of times over the years.
| # | Name | Took Office | Left Office | Party |
|---|---|---|---|---|
| 1. | Ernest Blythe | June 17, 1919 | September 9, 1922 | Sinn Féin |
| 2. | Joeseph McGrath | August 30, 1922 | March 7, 1925 | Cumann na nGaedhael |
| 3. | Patrick McGilligan | April 4, 1924 | March 9, 1932 | Cumann na nGaedhael |
| 4. | Sean Lemass (1st time) | March 9, 1932 | September 16, 1939 | Fianna Fáil |
| 5. | Seán MacEntee | September 16, 1939 | August 18, 1941 | Fianna Fáil |
| Sean Lemass (2nd time) | August 18, 1941 | February 18, 1948 | Fianna Fáil | |
| 6. | Daniel Morrissey | February 18, 1948 | March 7, 1951 | Fine Gael |
| 7. | Thomas F. O'Higgins | March 7, 1951 | June 13, 1951 | Fine Gael |
| Sean Lemass (3rd time) | June 13, 1951 | June 2, 1954 | Fianna Fáil | |
| 8. | William Norton | June 2, 1954 | March 20, 1957 | Labour |
| Sean Lemass (4th time) | March 20, 1957 | June 23, 1959 | Fianna Fáil | |
| 9. | Jack Lynch | June 23, 1959 | April 21, 1965 | Fianna Fáil |
| 10. | Patrick Hillery | April 21, 1965 | July 13, 1966 | Fianna Fáil |
| 11. | George Colley | July 13, 1966 | May 9, 1970 | Fianna Fáil |
| 12. | Patrick Lalor | May 9, 1970 | March 14, 1973 | Fianna Fáil |
| 13. | Justin Keating | March 14, 1973 | July 5, 1977 | Fine Gael |
| 14. | Desmond O'Malley (1st time) | July 5, 1977 | June 30, 1981 | Fianna Fáil |
| 15. | John Kelly | June 30, 1981 | March 9, 1982 | Fine Gael |
| Desmond O'Malley (2nd time) | March 9, 1982 | October 6, 1982 | Fianna Fáil | |
| 16. | Patrick Power | October 7, 1982 | October 27, 1982 | Fianna Fáil |
| 17. | Pádraig Flynn (1st time) | October 27, 1982 | December 14, 1982 | Fianna Fáil |
| 18. | Frank Cluskey | December 14, 1982 | December 8, 1983 | Labour |
| 19. | Garret FitzGerald (acting) | December 8, 1983 | December 13, 1983 | Fine Gael |
| 20. | John Bruton | December 13, 1983 | February 14, 1986 | Fine Gael |
| 21. | Michael Noonan | February 14, 1986 | March 10, 1987 | Fine Gael |
| 22. | Albert Reynolds | March 10, 1987 | November 24, 1988 | Fianna Fáil |
| 23. | Ray Burke | November 24, 1988 | July 12, 1989 | Fianna Fáil |
| 24. | Desmond O'Malley (3rd time) | July 12, 1989 | November 4, 1992 | Progressive Democrats |
| 25. | Pádraig Flynn (2nd time) | November 5, 1992 | January 4, 1993 | Fianna Fáil |
| 26. | Bertie Ahern | January 4, 1993 | January 12, 1993 | Fianna Fáil |
| 27. | Ruairí Quinn | January 12, 1993 | November 17, 1994 | Labour |
| 28. | Charlie McCreevy | November 18, 1994 | December 15, 1994 | Fianna Fáil |
| 29. | Richard Bruton | December 15, 1994 | June 26, 1997 | Fine Gael |
| 30. | Mary Harney | June 26, 1997 | (still in office) | Progressive Democrats |