There are two places named Big Four in the United States.

• Big Four in Snohomish County, Washington
• Big Four in McDowell County, West Virginia

Big Four is often used as a nickname:

• Big Four auditors.
• The 'Big Four' outlaw motorcycle gangs.
• a nickname for a railroad in the United States of America officially called the Cleveland, Cincinnati, Chicago and St. Louis Railroad (later absorbed by the New York Central Railroad).
• name given to the four biggest banks in Ireland, these are: Allied Irish Banks, Bank of Ireland, National Irish Bank (Northern Bank in Northern Ireland) and Ulster Bank.
• name given to the four biggest banks in the United Kingdom, these are: Lloyds TSB, the Royal Bank of Scotland, Barclays Bank and HSBC.
• name given to the four large banks in the People's Republic of China, these are the Bank of China, the China Construction Bank, the Industrial and Commercial Bank of China and the Agricultural Bank of China.
• The four major U.S. television networks: ABC, NBC, CBS and Fox
• The four major IRC Networks: Quakenet, Undernet, EFNet, IRCNet
• The Big Four was the collective name given to four railroad magnates in the western U.S.: Collis P. Huntington, Leland Stanford, Mark Hopkins and Charles Crocker
• The Big Four (novel) was an Agatha Christie book

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